ಅಭಿಪ್ರಾಯ / ಸಲಹೆಗಳು

ಸಂಶೋಧನಾ ಚಟುವಟಿಕೆಗಳು ಮತ್ತು ಅದರ ಪರಿಣಾಮ

ಎಂ.ಆರ್.‌ಯು ಸಂಶೋಧನಾ ಚಟುವಟಿಕೆಗಳು ಮತ್ತು ಅದರ ಪರಿಣಾಮ

Project 1: The study of lipid profile and cardiovascular risk factors in children born to parents having premature ischemic heart disease

Children born to parents with premature IHD have significant incidence of dyslipidemia compared to controls. There has been increased incidence of risk factors like increased BMI, excess junk food intake, sedentary life style in these children with dyslipidemia and family history of premature IHD

Therefore the current study recommends that children of premature IHD patients should be screened for dyslipidemia, so that dietary and life style measures can be instituted at the earliest.

Project 2: Insulin sensitivity and endothelial dysfunction among offsprings of Type 2 Diabetes Mellitus

As long term Applicability- atherosclerosis is a process that starts at an early life, which in turn is responsible for insulin resistance. Therefore the present study has an impact on early intervention by life style modification in diabetic offspring which in turn could retard the progression of diabetes in them in future.  Anti-inflammatory and anti-atherogenic properties of adiponectin and the ability to stimulate insulin sensitivity can make adiponectin a potential therapeutic option in future.

Project 3: Study of the association of non-alcoholic fatty liver disease (NAFLD) with type2 diabetes mellitus subjects and their first degree relatives

Strong association of T2DM and NAFLD is more recently recognized and less often investigated by physicians as they focus more on micro and macro vascular complications.  The study showed 73% of T2DM subjects having NAFLD. But in case of first degree relatives of T2DM, we found 23% of subjects are having NAFLD and 43% are Insulin resistant (IR). The study also showed 16% of first degree relatives having both NAFLD and IR. Further, IR and Impaired Glucose Tolerance among NAFLD subjects are more common when compared to non-NAFLD subjects (73% vs. 34% & 35% vs. 6%) in first degree relatives. Significant outcome of the study is that, association of NAFLD and insulin resistance can be found in first degree relatives of type 2 diabetes patients even in their normoglycemic status. Hence this calls for preventive measures to be taken in population at risk of type 2 diabetes.

Project 4: Evaluation of biochemical markers and gene polymorphism in subjects with osteoporotic fractures

The bone markers (osteocalcin & beta crosslaps) may help predicting the bone loss in patients who are at risk of osteoporotic fracture. The association of APOE4 genotype with bone turnover markers may assist in identifying subjects who are susceptible for osteoporotic fractures. This study may help in monitoring the skeletal response to treatment and encouraging patient compliance.

Project 5: A study of vitamin D and parathormone levels and its association with insulin resistance and obesity in type 2 diabetic subjects and their first degree relatives

The present study has thrown some light on the correlation between vitamin D and Parathormone levels in type -2 Diabetic subjects, in pre diabetics (their first degree relatives) and in obesity. It has also given information about the association of these analytes with insulin resistance. The present study has some insight that PTH status needs to be considered when evaluating the associations of Vitamin D status with glucose homeostasis and its underlying determinants. 

This project has provided novel pathophysiologic insight relevant to Vitamin D status on Type 2 Diabetes Mellitus and Their First degree relatives and has provided valuable information as to equally consider the PTH status also into consideration during future clinical trials of Vitamin D supplementation (which has not provided consistent and significant benefits in earlier studies).

Project 6: A Study of adiponectin gene polymorphism among offsprings of Type 2 Diabetes Mellitus

The serum adiponectin concentration has a strong genetic component, with heritability estimated at 88%. Genetic predisposition for diabetes may influence adiponectin gene expression leading to decrease in its plasma concentration, which might play a key role in developing diabetes in near future. This study may help in understanding the possible role and influence of adiponectin gene polymorphism particularly SNP 45T>G in initiating the lead towards developing diabetes in near future.  SNP45T>G in adiponectin gene may be one of the important risk factor for the early insulin resistance and could help in developing personalized medicine and to take preventive measures.

 

 

ಇತ್ತೀಚಿನ ನವೀಕರಣ​ : 25-02-2020 10:31 AM ಅನುಮೋದಕರು: DRNANJARAJ


ಹಕ್ಕುತ್ಯಾಗ

ಈ ಪುಟವು ಸರ್ಕಾರಿ ಸಚಿವಾಲಯ/ ಇಲಾಖೆ/ ಸಂಸ್ಥೆಗಳಿಗೂ ಲಿಂಕುಗಳನ್ನು ಕಲ್ಪಿಸುತ್ತದೆ ಎಂಬುದನ್ನು ದಯವಿಟ್ಟು ಗಮನಿಸಿ. ಈ ವೆಬ್ ಸೈಟುಗಳ ವಿಷಯಗಳು ಆಯಾ ಸಂಸ್ಥೆಗಳ ಸ್ವತ್ತೇ ಆಗಿದ್ದು, ಯಾವುದೇ ಹೆಚ್ಚಿನ ಮಾಹಿತಿ ಅಥವಾ ಸಲಹೆಗಾಗಿ ಅವರನ್ನೇ ಸಂಪರ್ಕಿಸುವುದು

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